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Drug-Drug Interaction (DDI)

DDI
Clinical

A change in a drug's effect when administered with another drug. Pharmacokinetic DDIs alter ADME (e.g., CYP inhibition/induction). Pharmacodynamic DDIs alter drug effect (e.g., synergism, antagonism).

Exemplos

  • Ketoconazole + simvastatin (CYP3A4)
  • Warfarin + aspirin (PD)
  • Methotrexate + NSAIDs (renal CL)

Você sabia?

A change in a drug's effect when administered with another drug. Pharmacokinetic DDIs alter ADME (e.g., CYP inhibition/induction). Pharmacodynamic DDIs alter drug effect (e.g., synergism, antagonism).