Lipinski's Rule of Five (Ro5)

Ro5

Chemistry

An empirical guideline predicting oral bioavailability. A drug-like compound should have: MW <= 500, LogP <= 5, HBD <= 5, HBA <= 10. Violations suggest poor absorption. Biologics are notable exceptions.

Exemplos

Most oral drugs comply
Biologics violate (MW >>500)
Beyond Ro5 space exploration

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An empirical guideline predicting oral bioavailability. A drug-like compound should have: MW <= 500, LogP <= 5, HBD <= 5, HBA <= 10. Violations suggest poor absorption. Biologics are notable …