Maintenance Dose

Pharmacokinetics

The dose given at regular intervals to maintain steady-state therapeutic concentrations. Equals the amount eliminated per dosing interval. Adjusted for renal/hepatic impairment.

Exemplos

MD = CL * Css * tau / F
Renal dose adjustment for aminoglycosides
Hepatic dose adjustment for opioids

Você sabia?

The dose given at regular intervals to maintain steady-state therapeutic concentrations. Equals the amount eliminated per dosing interval. Adjusted for renal/hepatic impairment.