Maximum Tolerated Dose (MTD)

MTD

Toxicology

The highest dose of a drug that does not cause unacceptable toxicity. Determined in dose-escalation Phase I studies. Critical for oncology drugs where efficacy often correlates with dose intensity.

Exemplos

3+3 dose escalation design
Dose-limiting toxicity (DLT)
MTD-based dosing in oncology

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The highest dose of a drug that does not cause unacceptable toxicity. Determined in dose-escalation Phase I studies. Critical for oncology drugs where efficacy often correlates with dose intensity.