OCT2 (OCT2)
OCT2Organic Cation Transporter 2 (gene: SLC22A2), the primary renal uptake transporter for organic cations, expressed on the basolateral membrane of renal proximal tubule cells. Mediates the first step of renal cation secretion and is a key determinant of metformin renal clearance. FDA guidance recommends evaluation of OCT2 interactions for renally cleared cationic drugs.
Exemplos
- Metformin renal secretion (OCT2 uptake + MATE1/2-K efflux)
- Cisplatin nephrotoxicity driven by OCT2-mediated tubular accumulation
- Cimetidine inhibition of OCT2 reducing metformin renal clearance
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Organic Cation Transporter 2 (gene: SLC22A2), the primary renal uptake transporter for organic cations, expressed on the basolateral membrane of renal proximal tubule cells. Mediates the first step of renal …