Population Pharmacokinetics (PopPK)

A modeling approach that characterizes the typical pharmacokinetic parameters and their variability across a patient population, using sparse sampling data from many individuals. Non-linear mixed effects modeling (NONMEM) is the standard tool, quantifying inter-individual variability, residual error, and covariate effects such as body weight, renal function, and genetic polymorphisms. PopPK supports dose individualization and regulatory submissions.

Exemplos

• Busulfan PopPK model for weight-based dosing in pediatric transplant patients
• Vancomycin Bayesian dosing guided by PopPK models in critically ill patients
• Monoclonal antibody PopPK to characterize target-mediated disposition