Steady State (Css)

Css

Pharmacokinetics

The condition where drug input rate equals elimination rate, resulting in stable plasma concentrations. Achieved after approximately 5 half-lives of repeated dosing regardless of dose or interval.

Exemplos

Css reached in ~5 half-lives
Loading dose to achieve Css faster
Css = F * dose / (CL * tau)

Você sabia?

The condition where drug input rate equals elimination rate, resulting in stable plasma concentrations. Achieved after approximately 5 half-lives of repeated dosing regardless of dose or interval.