Descrição

Diazepam and diphenhydramine produce additive CNS depression, with risk of profound sedation, cognitive impairment, and falls.

Mecanismo

Diazepam potentiates GABA-A inhibition; diphenhydramine blocks H1 receptors causing sedation and has anticholinergic effects — additive CNS depression occurs.

Significância Clínica

Particularly hazardous in elderly patients; both drugs appear on the Beers Criteria as potentially inappropriate in older adults.

Conduta

Avoid combination especially in elderly; use non-sedating antihistamines and minimize benzodiazepine duration.

Aviso Médico

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.