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EGFR (Epidermal Growth Factor Receptor)

EGFR

Receptor tyrosine kinase driving cell proliferation, commonly mutated in NSCLC.

Função

Activating mutations drive oncogenic signaling. Targeted by TKIs (erlotinib, osimertinib) and antibodies (cetuximab).

Related Targets

CDK4/CDK6 (Cyclin-Dependent Kinase 4/6) CDK4/CDK6 MTOR (Mechanistic Target of Rapamycin) MTOR BRAF (BRAF Kinase) BRAF BCR-ABL1 (BCR-ABL Fusion Protein) BCR-ABL1 KDR (Vascular Endothelial Growth Factor Receptor 2) KDR ALK (Anaplastic Lymphoma Kinase) ALK