SCN9A (Sodium Channel Nav1.7)
SCN9A
Voltage-gated sodium channel preferentially expressed in nociceptive neurons.
Function
Gain-of-function mutations cause inherited pain disorders. Blocking reduces pain signaling.
Drugs Acting on This Target
| Drug | Action | Primary |
|---|---|---|
| Valproic Acid | Blocker | Yes |
| Topiramate | Blocker | Yes |
| Phenytoin | Blocker | Yes |
| Gabapentin | Blocker | Yes |
| Pregabalin | Blocker | Yes |
| Lamotrigine | Blocker | Yes |
| Carbamazepine | Blocker | Yes |
| Furosemide | Inhibitor | Yes |
| Hydrochlorothiazide | Inhibitor | Yes |