Bupropion

CHEMBL894 Phase 4 ได้รับการอนุมัติ Small molecule

Half-Life

21 hours

Bioavailability

—

Protein Binding

—

Molecular Weight

239.7 g/mol

LogP

3.2

Phase

4

Distinct among antidepressants for not typically causing sexual dysfunction or weight gain, bupropion inhibits the reuptake of norepinephrine and dopamine rather than serotonin. It treats major depressive disorder and seasonal affective disorder and, under separate branding, aids smoking cessation. Sold as Wellbutrin, Aplenzin, and Zyban, it has the formula C13H18ClNO. Because it lowers the seizure threshold in a dose-dependent way, its use is limited in patients with seizure risk. This monocyclic aminoketone remains one of the more commonly prescribed non-serotonergic antidepressants.

An antidepressant and smoking cessation aid that inhibits the reuptake of norepinephrine and dopamine in the brain. It is used to treat major depressive disorder, seasonal affective disorder, and to help people quit smoking. Unlike many antidepressants, it does not typically cause sexual dysfunction or weight gain, and is associated with a dose-dependent risk of seizures.

น้ำหนักโมเลกุล

239.7420 g/mol

LogP

3.20

TPSA

29.10 Å²

Lipinski RO5

ผ่าน

ด้านการรักษา

Neurology Psychiatry Epilepsy Major Depressive Disorder

หมวดหมู่ยา

N — N - Nervous System

Pharmacokinetics (PK)

Half-Life 21 hours

Pharmacodynamics (PD)

โครงสร้าง 2 มิติ

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SMILES

CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1

InChI

InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3

Molecular Formula

C13H18ClNO

HBD / HBA

1 / 2

พันธะที่หมุนได้

4

อะตอมหนัก

16

CYP2D6 (Cytochrome P450 2D6) Inhibitor

Major Bupropion + Tramadol

Bupropion combined with tramadol increases the risk of both serotonin syndrome and seizures, representing a serious dual-hazard drug combination.

Moderate Bupropion + Venlafaxine

Bupropion inhibits CYP2D6, significantly increasing venlafaxine plasma concentrations, which may enhance both therapeutic and adverse serotonergic effects.

Moderate Bupropion + Quetiapine

Bupropion inhibits CYP2D6, modestly increasing quetiapine levels, while also lowering the seizure threshold — both risks are additive.

Moderate Bupropion + Metoprolol

Bupropion is a potent CYP2D6 inhibitor that substantially increases metoprolol plasma concentrations, potentially causing excessive beta-blockade (bradycardia, hypotension, heart block).

Moderate Bupropion + Aripiprazole

Bupropion, a CYP2D6 inhibitor, significantly increases aripiprazole plasma concentrations, increasing the risk of dose-dependent adverse effects.

No side effects recorded

Side effect data is not yet available for this drug.

คำถามที่พบบ่อย

An antidepressant and smoking cessation aid that inhibits the reuptake of norepinephrine and dopamine in the brain. It is used to treat major depressive disorder, seasonal affective disorder, and to help people quit smoking. Unlike many antidepressants, it does not typically cause sexual dysfunction or weight gain, and is associated with a dose-dependent risk of seizures.

Key pharmacokinetic parameters for Bupropion: Half-life: 21 hours.

Yes, Bupropion is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

Related Drugs

Same Drug Class

Acetaminophen Small molecule Aspirin Small molecule Sertraline Small molecule Escitalopram Small molecule

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL894. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 444. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.

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โครงสร้าง

ข้อมูลด่วน

Class: N - Nervous System
สูตร: C13H18ClNO
คำพ้องความหมาย: 17

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This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.