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Bupropion

CHEMBL894 Phase 4 Đã phê duyệt Small molecule
Half-Life
21 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
239.7 g/mol
LogP
3.2
Phase
4

An antidepressant and smoking cessation aid that inhibits the reuptake of norepinephrine and dopamine in the brain. It is used to treat major depressive disorder, seasonal affective disorder, and to help people quit smoking. Unlike many antidepressants, it does not typically cause sexual dysfunction or weight gain, and is associated with a dose-dependent risk of seizures.

Khối lượng phân tử

239,7420 g/mol

LogP

3,20

TPSA

29,10 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Cardiovascular Disease Pain Management Non-Small Cell Lung Cancer Chronic Obstructive Pulmonary Disease Alzheimer's Disease Epilepsy Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Insomnia Melanoma Inflammatory Bowel Disease Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Stroke Obesity Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Chronic Pain HIV/AIDS Tuberculosis Heart Failure Prostate Cancer Colorectal Cancer Leukemia

Phân loại thuốc

N — N - Nervous System

Cơ chế tác dụng

Norepinephrine-dopamine reuptake inhibitor (NDRI).

Pharmacokinetics (PK)

Half-Life 21 hours

Pharmacodynamics (PD)

Cơ chế

Norepinephrine-dopamine reuptake inhibitor (NDRI).

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C13H18ClNO

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
Liên kết có thể quay

                        
4

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
16

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            CYP2D6 (Cytochrome P450 2D6)
                            Inhibitor
                        

                        
                        Primary Target
                        
                    

                    
                    

                        

                            SLC6A4 (Serotonin Transporter)
                            Inhibitor
                        

                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Bupropion + Tramadol
                            
                        

                        
                        
Bupropion combined with tramadol increases the risk of both serotonin syndrome and seizures, representing a serious dual-hazard drug combination.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Bupropion + Venlafaxine
                            
                        

                        
                        
Bupropion inhibits CYP2D6, significantly increasing venlafaxine plasma concentrations, which may enhance both therapeutic and adverse serotonergic effects.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Bupropion + Quetiapine
                            
                        

                        
                        
Bupropion inhibits CYP2D6, modestly increasing quetiapine levels, while also lowering the seizure threshold — both risks are additive.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Bupropion + Metoprolol
                            
                        

                        
                        
Bupropion is a potent CYP2D6 inhibitor that substantially increases metoprolol plasma concentrations, potentially causing excessive beta-blockade (bradycardia, hypotension, heart block).

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Bupropion + Aripiprazole
                            
                        

                        
                        
Bupropion, a CYP2D6 inhibitor, significantly increases aripiprazole plasma concentrations, increasing the risk of dose-dependent adverse effects.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
An antidepressant and smoking cessation aid that inhibits the reuptake of norepinephrine and dopamine in the brain. It is used to treat major depressive disorder, seasonal affective disorder, and to help people quit smoking. Unlike many antidepressants, it does not typically cause sexual dysfunction or weight gain, and is associated with a dose-dependent risk of seizures.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Norepinephrine-dopamine reuptake inhibitor (NDRI).

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Bupropion: Half-life: 21 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Bupropion is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Acetaminophen
                            Small molecule
                        
                        
                        
                            Aspirin
                            Small molecule
                        
                        
                        
                            Sertraline
                            Small molecule
                        
                        
                        
                            Escitalopram
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL894.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 444.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.