Chloroform
A halogenated hydrocarbon historically used as a general anesthetic and sedative that produces CNS depression through mechanisms affecting chloride channels and other neuronal targets. Its use in medicine has been entirely abandoned due to its narrow therapeutic index, hepatotoxicity, nephrotoxicity, and potential carcinogenicity. It now has only research and industrial chemical applications.
น้ำหนักโมเลกุล
119.3700 g/mol
LogP
2.30
TPSA
0.00 Ų
Lipinski RO5
ผ่าน
ด้านการรักษา
กลไกการออกฤทธิ์
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
โครงสร้าง 2 มิติ
Cite this structure
Embed this structure
SMILES
ClC(Cl)Cl
InChI
InChI=1S/CHCl3/c2-1(3)4/h1H
Molecular Formula
CHCl3
HBD / HBA
- / -
พันธะที่หมุนได้
0
อะตอมหนัก
4
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
คำถามที่พบบ่อย
A halogenated hydrocarbon historically used as a general anesthetic and sedative that produces CNS depression through mechanisms affecting chloride channels and other neuronal targets. Its use in medicine has been entirely abandoned due to its narrow therapeutic index, hepatotoxicity, nephrotoxicity, and potential carcinogenicity. It now has only research and industrial chemical applications.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Chloroform is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL44618. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6212. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
ข้อจำกัดความรับผิดชอบทางการแพทย์
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
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