Chloroform
A halogenated hydrocarbon historically used as a general anesthetic and sedative that produces CNS depression through mechanisms affecting chloride channels and other neuronal targets. Its use in medicine has been entirely abandoned due to its narrow therapeutic index, hepatotoxicity, nephrotoxicity, and potential carcinogenicity. It now has only research and industrial chemical applications.
分子量
119.3700 g/mol
LogP
2.30
TPSA
0.00 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
二维结构
Cite this structure
Embed this structure
SMILES
ClC(Cl)Cl
InChI
InChI=1S/CHCl3/c2-1(3)4/h1H
Molecular Formula
CHCl3
HBD / HBA
- / -
可旋转键数
0
重原子数
4
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A halogenated hydrocarbon historically used as a general anesthetic and sedative that produces CNS depression through mechanisms affecting chloride channels and other neuronal targets. Its use in medicine has been entirely abandoned due to its narrow therapeutic index, hepatotoxicity, nephrotoxicity, and potential carcinogenicity. It now has only research and industrial chemical applications.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Chloroform is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL44618. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6212. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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