Chloroform
A halogenated hydrocarbon historically used as a general anesthetic and sedative that produces CNS depression through mechanisms affecting chloride channels and other neuronal targets. Its use in medicine has been entirely abandoned due to its narrow therapeutic index, hepatotoxicity, nephrotoxicity, and potential carcinogenicity. It now has only research and industrial chemical applications.
Peso Molecular
119,3700 g/mol
LogP
2,30
TPSA
0,00 Ų
Regra dos 5 de Lipinski
Aprovado
Áreas Terapêuticas
Mecanismo de Ação
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Estrutura 2D
Cite this structure
Embed this structure
SMILES
ClC(Cl)Cl
InChI
InChI=1S/CHCl3/c2-1(3)4/h1H
Molecular Formula
CHCl3
HBD / HBA
- / -
Ligações Rotacionáveis
0
Átomos Pesados
4
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Perguntas frequentes
A halogenated hydrocarbon historically used as a general anesthetic and sedative that produces CNS depression through mechanisms affecting chloride channels and other neuronal targets. Its use in medicine has been entirely abandoned due to its narrow therapeutic index, hepatotoxicity, nephrotoxicity, and potential carcinogenicity. It now has only research and industrial chemical applications.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Chloroform is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL44618. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6212. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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