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Sulfadoxine

CHEMBL1539 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
310.3 g/mol
LogP
0.7
Phase
4

Sulfadoxine is a long-acting sulfonamide antibiotic used in combination with pyrimethamine (Fansidar) for the treatment and prevention of malaria caused by susceptible Plasmodium falciparum strains, particularly for intermittent preventive treatment in pregnancy and in malaria-endemic regions. The combination exploits sequential blockade of the folate synthesis pathway: sulfadoxine inhibits dihydropteroate synthase while pyrimethamine inhibits dihydrofolate reductase, providing synergistic antiparasitic activity. Resistance has limited its use in some geographic areas.

น้ำหนักโมเลกุล

310.3300 g/mol

LogP

0.70

TPSA

125.00 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Malaria HIV/AIDS

กลไกการออกฤทธิ์

Disrupts essential metabolic pathways or structural components of parasitic organisms, leading to paralysis, starvation, or death of the parasite.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

กลไก

Disrupts essential metabolic pathways or structural components of parasitic organisms, leading to paralysis, starvation, or death of the parasite.

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC

                

                

                
                

                    
InChI

                    
InChI=1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)

                

                

                

                    
                    

                        
Molecular Formula

                        
C12H14N4O4S

                    

                    
                    

                        
HBD / HBA

                        
2 / 8

                    

                    
                    

                        
พันธะที่หมุนได้

                        
5

                    

                    
                    
                    

                        
อะตอมหนัก

                        
21

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Sulfadoxine is a long-acting sulfonamide antibiotic used in combination with pyrimethamine (Fansidar) for the treatment and prevention of malaria caused by susceptible Plasmodium falciparum strains, particularly for intermittent preventive treatment in pregnancy and in malaria-endemic regions. The combination exploits sequential blockade of the folate synthesis pathway: sulfadoxine inhibits dihydropteroate synthase while pyrimethamine inhibits dihydrofolate reductase, providing synergistic antiparasitic activity. Resistance has limited its use in some geographic areas.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Disrupts essential metabolic pathways or structural components of parasitic organisms, leading to paralysis, starvation, or death of the parasite.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Sulfadoxine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1539.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 17134.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.