Sulfadoxine
Sulfadoxine is a long-acting sulfonamide antibiotic used in combination with pyrimethamine (Fansidar) for the treatment and prevention of malaria caused by susceptible Plasmodium falciparum strains, particularly for intermittent preventive treatment in pregnancy and in malaria-endemic regions. The combination exploits sequential blockade of the folate synthesis pathway: sulfadoxine inhibits dihydropteroate synthase while pyrimethamine inhibits dihydrofolate reductase, providing synergistic antiparasitic activity. Resistance has limited its use in some geographic areas.
分子量
310.3300 g/mol
LogP
0.70
TPSA
125.00 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Disrupts essential metabolic pathways or structural components of parasitic organisms, leading to paralysis, starvation, or death of the parasite.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts essential metabolic pathways or structural components of parasitic organisms, leading to paralysis, starvation, or death of the parasite.
二维结构
Cite this structure
Embed this structure
SMILES
COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC
InChI
InChI=1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
Molecular Formula
C12H14N4O4S
HBD / HBA
2 / 8
可旋转键数
5
重原子数
21
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Sulfadoxine is a long-acting sulfonamide antibiotic used in combination with pyrimethamine (Fansidar) for the treatment and prevention of malaria caused by susceptible Plasmodium falciparum strains, particularly for intermittent preventive treatment in pregnancy and in malaria-endemic regions. The combination exploits sequential blockade of the folate synthesis pathway: sulfadoxine inhibits dihydropteroate synthase while pyrimethamine inhibits dihydrofolate reductase, providing synergistic antiparasitic activity. Resistance has limited its use in some geographic areas.
Disrupts essential metabolic pathways or structural components of parasitic organisms, leading to paralysis, starvation, or death of the parasite.
Yes, Sulfadoxine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1539. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 17134. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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