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Tipiracil

CHEMBL235668 Phase 4 ได้รับการอนุมัติ Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
242.7 g/mol
LogP
-0.7
Phase
4

Tipiracil is a thymidine phosphorylase inhibitor that blocks the enzymatic degradation of trifluridine (TAS-102 combination partner) in the gut and blood, maintaining therapeutic trifluridine plasma concentrations. When combined with trifluridine, it enables sufficient systemic trifluridine exposure to incorporate into tumor cell DNA and inhibit thymidylate synthase, exerting cytotoxic effects. The combination is approved for refractory metastatic colorectal cancer and gastric cancer.

น้ำหนักโมเลกุล

242.6600 g/mol

LogP

-0.70

TPSA

85.30 Ų

Lipinski RO5

ผ่าน

ด้านการรักษา

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Breast Cancer Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

โครงสร้าง 2 มิติ

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
N=C1CCCN1Cc1[nH]c(=O)[nH]c(=O)c1Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16)

                

                

                

                    
                    

                        
Molecular Formula

                        
C9H11ClN4O2

                    

                    
                    

                        
HBD / HBA

                        
3 / 3

                    

                    
                    

                        
พันธะที่หมุนได้

                        
2

                    

                    
                    
                    

                        
อะตอมหนัก

                        
16

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
คำถามที่พบบ่อย

                

                    
                    

                        
                        

                            
Tipiracil is a thymidine phosphorylase inhibitor that blocks the enzymatic degradation of trifluridine (TAS-102 combination partner) in the gut and blood, maintaining therapeutic trifluridine plasma concentrations. When combined with trifluridine, it enables sufficient systemic trifluridine exposure to incorporate into tumor cell DNA and inhibit thymidylate synthase, exerting cytotoxic effects. The combination is approved for refractory metastatic colorectal cancer and gastric cancer.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Tipiracil is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL235668.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6323266.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
ข้อจำกัดความรับผิดชอบทางการแพทย์

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.