Antibody-Drug Conjugate (ADC)

A class of biopharmaceutical drugs that combine a monoclonal antibody specific to a tumor-associated antigen with a cytotoxic payload via a chemical linker. The antibody directs the conjugate to target cells, where internalization and linker cleavage release the cytotoxic agent intracellularly. Achieves targeted drug delivery that improves the therapeutic index compared to systemic chemotherapy.

ตัวอย่าง

• Enhertu (trastuzumab deruxtecan) for HER2+ breast cancer
• Adcetris (brentuximab vedotin) for Hodgkin lymphoma
• Padcev (enfortumab vedotin) for urothelial carcinoma