คำอธิบาย
Ciprofloxacin and ondansetron both prolong the QT interval; combined use raises the risk of torsades de pointes and sudden cardiac death.
กลไก
Both agents block hERG (IKr) cardiac potassium channels; additive QTc prolongation results from concurrent administration.
ความสำคัญทางคลินิก
Fluoroquinolones are a well-established class of QT-prolonging drugs; post-marketing data link the combination to arrhythmia events.
การจัดการ
Avoid when possible; if both are medically necessary, obtain baseline and follow-up ECG and correct electrolyte abnormalities.
ข้อจำกัดความรับผิดชอบทางการแพทย์
This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.