Major
Probable
Açıklama
Ciprofloxacin and ondansetron both prolong the QT interval; combined use raises the risk of torsades de pointes and sudden cardiac death.
Mekanizma
Both agents block hERG (IKr) cardiac potassium channels; additive QTc prolongation results from concurrent administration.
Klinik Önemi
Fluoroquinolones are a well-established class of QT-prolonging drugs; post-marketing data link the combination to arrhythmia events.
Yönetim
Avoid when possible; if both are medically necessary, obtain baseline and follow-up ECG and correct electrolyte abnormalities.