Decitabine

CHEMBL1201129 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

228.2 g/mol

LogP

-1.2

Phase

4

A hypomethylating agent that is incorporated into DNA and inhibits DNA methyltransferase, reactivating silenced tumor suppressor genes; used for myelodysplastic syndromes and acute myeloid leukemia. At low doses it has epigenetic effects distinct from its cytotoxic activity at higher doses.

Moleküler Ağırlık

228,2100 g/mol

LogP

-1,20

TPSA

121,00 Å²

Lipinski RO5

Geçer

Terapötik Alanlar

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Osteoporosis Melanoma Lymphoma Hypertension Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

SVG PNG

Cite this structure

Embed this structure

SMILES

Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1

InChI

InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1

Molecular Formula

C8H12N4O4

HBD / HBA

3 / 4

Döndürülebilir Bağlar

2

Ağır Atomlar

16

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

A hypomethylating agent that is incorporated into DNA and inhibits DNA methyltransferase, reactivating silenced tumor suppressor genes; used for myelodysplastic syndromes and acute myeloid leukemia. At low doses it has epigenetic effects distinct from its cytotoxic activity at higher doses.

Yes, Decitabine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201129. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 451668. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Hızlı Veriler

Formül: C8H12N4O4
Eş Anlamlılar: 1

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Tıbbi Sorumluluk Reddi

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.