Rofecoxib

CHEMBL122 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

314.4 g/mol

LogP

2.3

Phase

4

A selective COX-2 inhibitor that was used to treat pain and inflammation in arthritis and other conditions, withdrawn from the market in 2004 due to an increased risk of heart attack and stroke with long-term use. It represented an important lesson in the cardiovascular risks associated with some anti-inflammatory medications.

Moleküler Ağırlık

314,4000 g/mol

LogP

2,30

TPSA

68,80 Å²

Lipinski RO5

Geçer

Terapötik Alanlar

Pain Management Non-Small Cell Lung Cancer Rheumatoid Arthritis Chronic Pain Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

SVG PNG

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SMILES

CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1

InChI

InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3

Molecular Formula

C17H14O4S

HBD / HBA

- / 4

Döndürülebilir Bağlar

3

Ağır Atomlar

22

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

A selective COX-2 inhibitor that was used to treat pain and inflammation in arthritis and other conditions, withdrawn from the market in 2004 due to an increased risk of heart attack and stroke with long-term use. It represented an important lesson in the cardiovascular risks associated with some anti-inflammatory medications.

Yes, Rofecoxib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL122. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5090. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Hızlı Veriler

Formül: C17H14O4S

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Tıbbi Sorumluluk Reddi

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.