Rofecoxib

CHEMBL122 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

314.4 g/mol

LogP

2.3

Phase

4

A selective COX-2 inhibitor that was used to treat pain and inflammation in arthritis and other conditions, withdrawn from the market in 2004 due to an increased risk of heart attack and stroke with long-term use. It represented an important lesson in the cardiovascular risks associated with some anti-inflammatory medications.

分子量

314.4000 g/mol

LogP

2.30

TPSA

68.80 Å²

Lipinski 五规则

符合

治疗领域

Pain Management Non-Small Cell Lung Cancer Rheumatoid Arthritis Chronic Pain Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1

InChI

InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3

Molecular Formula

C17H14O4S

HBD / HBA

- / 4

可旋转键数

3

重原子数

22

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

A selective COX-2 inhibitor that was used to treat pain and inflammation in arthritis and other conditions, withdrawn from the market in 2004 due to an increased risk of heart attack and stroke with long-term use. It represented an important lesson in the cardiovascular risks associated with some anti-inflammatory medications.

Yes, Rofecoxib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL122. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 5090. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Rofecoxib 在 PillFYI 上

结构

快速数据

分子式: C17H14O4S

外部链接

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.