Thenalidine

CHEMBL2105458 Phase 4 Onaylandı Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

286.4 g/mol

LogP

3.8

Phase

4

Thenalidine is a first-generation antihistamine with anticholinergic and anti-serotonin properties that blocks H1 histamine receptors, used historically for allergic conditions including urticaria and pruritus. It was withdrawn from markets due to serious hematological adverse effects including agranulocytosis and neutropenia. Its sedative properties were typical of first-generation antihistamines due to CNS histamine H1 receptor blockade.

Moleküler Ağırlık

286,4000 g/mol

LogP

3,80

TPSA

34,70 Å²

Lipinski RO5

Geçer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D Yapı

SVG PNG

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SMILES

CN1CCC(N(Cc2cccs2)c2ccccc2)CC1

InChI

InChI=1S/C17H22N2S/c1-18-11-9-16(10-12-18)19(14-17-8-5-13-20-17)15-6-3-2-4-7-15/h2-8,13,16H,9-12,14H2,1H3

Molecular Formula

C17H22N2S

HBD / HBA

- / 3

Döndürülebilir Bağlar

4

Ağır Atomlar

20

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Sıkça Sorulan Sorular

Thenalidine is a first-generation antihistamine with anticholinergic and anti-serotonin properties that blocks H1 histamine receptors, used historically for allergic conditions including urticaria and pruritus. It was withdrawn from markets due to serious hematological adverse effects including agranulocytosis and neutropenia. Its sedative properties were typical of first-generation antihistamines due to CNS histamine H1 receptor blockade.

Yes, Thenalidine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105458. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 27901. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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Formül: C17H22N2S

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This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.