Zanamivir
Zanamivir is a neuraminidase inhibitor that competitively blocks the influenza virus neuraminidase enzyme, preventing cleavage of sialic acid from host cell surface glycoproteins and inhibiting viral release, spread, and penetration of respiratory mucus. It is inhaled via the Diskhaler device for treatment and prevention of influenza A and B infections. Its topical inhalation route limits systemic bioavailability while delivering high drug concentrations to the respiratory tract.
Moleküler Ağırlık
332,3100 g/mol
LogP
-3,20
TPSA
201,00 Ų
Lipinski RO5
Geçer
Terapötik Alanlar
Etki Mekanizması
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
2D Yapı
Cite this structure
Embed this structure
SMILES
CC(=O)N[C@H]1[C@H]([C@H](O)[C@H](O)CO)OC(C(=O)O)=C[C@@H]1NC(=N)N
InChI
InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1
Molecular Formula
C12H20N4O7
HBD / HBA
7 / 8
Döndürülebilir Bağlar
6
Ağır Atomlar
23
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Sıkça Sorulan Sorular
Zanamivir is a neuraminidase inhibitor that competitively blocks the influenza virus neuraminidase enzyme, preventing cleavage of sialic acid from host cell surface glycoproteins and inhibiting viral release, spread, and penetration of respiratory mucus. It is inhaled via the Diskhaler device for treatment and prevention of influenza A and B infections. Its topical inhalation route limits systemic bioavailability while delivering high drug concentrations to the respiratory tract.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Zanamivir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL222813. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 60855. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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