Partition Coefficient (LogP)
LogPThe ratio of a compound's concentration in two immiscible solvents (typically octanol/water). LogP measures intrinsic lipophilicity. Higher LogP indicates greater membrane permeability but poorer aqueous solubility.
Örnekler
- LogP < 0: highly hydrophilic
- LogP 1-3: good oral absorption
- LogP > 5: Lipinski violation
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The ratio of a compound's concentration in two immiscible solvents (typically octanol/water). LogP measures intrinsic lipophilicity. Higher LogP indicates greater membrane permeability but poorer aqueous solubility.