Partition Coefficient (LogP)
LogPThe ratio of a compound's concentration in two immiscible solvents (typically octanol/water). LogP measures intrinsic lipophilicity. Higher LogP indicates greater membrane permeability but poorer aqueous solubility.
Exemplos
- LogP < 0: highly hydrophilic
- LogP 1-3: good oral absorption
- LogP > 5: Lipinski violation
Você sabia?
The ratio of a compound's concentration in two immiscible solvents (typically octanol/water). LogP measures intrinsic lipophilicity. Higher LogP indicates greater membrane permeability but poorer aqueous solubility.