Major
Established
Açıklama
Co-prescribing two SSRIs leads to additive serotonin excess with no therapeutic benefit and high risk of serotonin syndrome.
Mekanizma
Both escitalopram and sertraline inhibit the serotonin transporter (SERT); concurrent use causes additive blockade and serotonin accumulation.
Klinik Önemi
Combination offers no evidence-based advantage and increases serotonin toxicity risk significantly.
Yönetim
Contraindicated; switch fully from one SSRI to another with appropriate washout period rather than combining.