Hydrochlorothiazide vs Metformin

## Hydrochlorothiazide vs Metformin: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Metformin**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Metformin**: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Metformin — 4-9 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Metformin — C4H11N5.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Metformin — 129.1640 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Metformin — Small molecule.