Cevimeline
A cholinergic agonist that stimulates muscarinic M3 receptors in exocrine glands, increasing saliva and tear production. It is indicated for the treatment of dry mouth in patients with Sjögren's syndrome. Common side effects reflect its muscarinic stimulation and include sweating, nausea, and urinary frequency.
Khối lượng phân tử
199,3200 g/mol
LogP
1,50
TPSA
37,80 Ų
Lipinski RO5
Đạt
Cơ chế tác dụng
Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
CC1OC2(CS1)CN1CCC2CC1
InChI
InChI=1S/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3
Molecular Formula
C10H17NOS
HBD / HBA
- / 3
Liên kết có thể quay
0
Nguyên tử nặng
13
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
A cholinergic agonist that stimulates muscarinic M3 receptors in exocrine glands, increasing saliva and tear production. It is indicated for the treatment of dry mouth in patients with Sjögren's syndrome. Common side effects reflect its muscarinic stimulation and include sweating, nausea, and urinary frequency.
Competitively blocks muscarinic acetylcholine receptors, reducing parasympathetic nervous system activity. Effects include decreased secretions, bronchodilation, and relaxation of smooth muscle.
Yes, Cevimeline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL168815. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 25137844. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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