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Chlorambucil

CHEMBL515 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
304.2 g/mol
LogP
1.7
Phase
4

An alkylating chemotherapy agent that crosslinks DNA strands in cancer cells, preventing replication and causing cell death. It is used to treat chronic lymphocytic leukemia, Hodgkin's and non-Hodgkin's lymphomas, and Waldenström's macroglobulinemia. It is one of the oldest and most well-established oral chemotherapy drugs, though it has been largely superseded by newer targeted therapies.

Khối lượng phân tử

304,2000 g/mol

LogP

1,70

TPSA

40,50 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
O=C(O)CCCc1ccc(N(CCCl)CCCl)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

                

                

                

                    
                    

                        
Molecular Formula

                        
C14H19Cl2NO2

                    

                    
                    

                        
HBD / HBA

                        
1 / 3

                    

                    
                    

                        
Liên kết có thể quay

                        
9

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
19

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
An alkylating chemotherapy agent that crosslinks DNA strands in cancer cells, preventing replication and causing cell death. It is used to treat chronic lymphocytic leukemia, Hodgkin's and non-Hodgkin's lymphomas, and Waldenström's macroglobulinemia. It is one of the oldest and most well-established oral chemotherapy drugs, though it has been largely superseded by newer targeted therapies.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Chlorambucil is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL515.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2708.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.