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Cidofovir

CHEMBL5314375 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
279.2 g/mol
LogP
-3.6
Phase
4

An antiviral nucleotide analog that inhibits viral DNA polymerase, used intravenously for cytomegalovirus (CMV) retinitis in patients with AIDS when other antivirals are contraindicated. Serious nephrotoxicity is the major dose-limiting toxicity, requiring co-administration of probenecid and aggressive intravenous hydration to reduce kidney damage. It is reserved for refractory or intolerant cases due to its toxicity profile.

Khối lượng phân tử

279,1900 g/mol

LogP

-3,60

TPSA

146,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Pain Management Epilepsy Migraine Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Insomnia Chronic Kidney Disease Hypertension Chronic Pain HIV/AIDS Heart Failure

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Nc1ccn(C[C@@H](CO)OCP(=O)(O)O)c(=O)n1.O.O

                

                

                
                

                    
InChI

                    
InChI=1S/C8H14N3O6P.2H2O/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16;;/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16);2*1H2/t6-;;/m0../s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C8H14N3O6P

                    

                    
                    

                        
HBD / HBA

                        
4 / 6

                    

                    
                    

                        
Liên kết có thể quay

                        
6

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
18

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
An antiviral nucleotide analog that inhibits viral DNA polymerase, used intravenously for cytomegalovirus (CMV) retinitis in patients with AIDS when other antivirals are contraindicated. Serious nephrotoxicity is the major dose-limiting toxicity, requiring co-administration of probenecid and aggressive intravenous hydration to reduce kidney damage. It is reserved for refractory or intolerant cases due to its toxicity profile.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Cidofovir is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL5314375.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 60613.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.