Cladribine
A purine nucleoside analog that selectively destroys lymphocytes by accumulating in cells with high deoxycytidine kinase activity and low 5'-nucleotidase activity, disrupting DNA synthesis and repair. It is used for hairy cell leukemia, multiple sclerosis, and other lymphoid malignancies. Profound and prolonged lymphopenia is a characteristic effect requiring careful infectious complication monitoring.
Khối lượng phân tử
285,6900 g/mol
LogP
0,80
TPSA
119,00 Ų
Lipinski RO5
Đạt
Lĩnh vực điều trị
Cơ chế tác dụng
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
Nc1nc(Cl)nc2c1ncn2[C@H]1C[C@H](O)[C@@H](CO)O1
InChI
InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
Molecular Formula
C10H12ClN5O3
HBD / HBA
3 / 7
Liên kết có thể quay
2
Nguyên tử nặng
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
A purine nucleoside analog that selectively destroys lymphocytes by accumulating in cells with high deoxycytidine kinase activity and low 5'-nucleotidase activity, disrupting DNA synthesis and repair. It is used for hairy cell leukemia, multiple sclerosis, and other lymphoid malignancies. Profound and prolonged lymphopenia is a characteristic effect requiring careful infectious complication monitoring.
Functions as a nucleoside analog that is incorporated into viral or cellular DNA/RNA during replication, causing chain termination or coding errors that inhibit pathogen proliferation.
Yes, Cladribine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1619. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 20279. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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