Cloxacillin

CHEMBL891 Phase 4 Đã phê duyệt Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

435.9 g/mol

LogP

2.4

Phase

4

A penicillinase-resistant penicillin antibiotic used to treat infections caused by staphylococci that produce beta-lactamase enzymes. It works by inhibiting bacterial cell wall synthesis and is taken orally on an empty stomach for best absorption.

Khối lượng phân tử

435,9000 g/mol

LogP

2,40

TPSA

138,00 Å²

Lipinski RO5

Đạt

Lĩnh vực điều trị

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Infectious Disease Chronic Kidney Disease Breast Cancer Atopic Dermatitis Prostate Cancer Colorectal Cancer

Cơ chế tác dụng

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), preventing transpeptidation and cross-linking of peptidoglycan chains. This weakens the bacterial cell wall, leading to osmotic lysis and cell death.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), preventing transpeptidation and cross-linking of peptidoglycan chains. This weakens the bacterial cell wall, leading to osmotic lysis and cell …

Cấu trúc 2D

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SMILES

Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@@H]1C(=O)N2[C@@H]1SC(C)(C)[C@@H]2C(=O)O

InChI

InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1

Molecular Formula

C19H18ClN3O5S

HBD / HBA

2 / 7

Liên kết có thể quay

4

Nguyên tử nặng

29

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Câu hỏi thường gặp

A penicillinase-resistant penicillin antibiotic used to treat infections caused by staphylococci that produce beta-lactamase enzymes. It works by inhibiting bacterial cell wall synthesis and is taken orally on an empty stomach for best absorption.

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), preventing transpeptidation and cross-linking of peptidoglycan chains. This weakens the bacterial cell wall, leading to osmotic lysis and cell death.

Yes, Cloxacillin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL891. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 6098. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Cấu trúc

Dữ liệu nhanh

Công thức: C19H18ClN3O5S
Tên đồng nghĩa: 2

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Tuyên bố miễn trách y tế

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.