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Delamanid

CHEMBL218650 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
534.5 g/mol
LogP
5.6
Phase
4

A nitro-dihydro-imidazooxazole antibiotic that inhibits mycobacterial cell wall synthesis by blocking the production of methoxy- and keto-mycolic acids, used for multidrug-resistant tuberculosis. It is reserved for TB cases where other options have been exhausted.

Khối lượng phân tử

534,5000 g/mol

LogP

5,60

TPSA

104,00 Ų

Lipinski RO5

Không đạt

Lĩnh vực điều trị

HIV/AIDS Tuberculosis

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
C[C@]1(COc2ccc(N3CCC(Oc4ccc(OC(F)(F)F)cc4)CC3)cc2)Cn2cc([N+](=O)[O-])nc2O1

                

                

                
                

                    
InChI

                    
InChI=1S/C25H25F3N4O6/c1-24(15-31-14-22(32(33)34)29-23(31)38-24)16-35-18-4-2-17(3-5-18)30-12-10-20(11-13-30)36-19-6-8-21(9-7-19)37-25(26,27)28/h2-9,14,20H,10-13,15-16H2,1H3/t24-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C25H25F3N4O6

                    

                    
                    

                        
HBD / HBA

                        
- / 11

                    

                    
                    

                        
Liên kết có thể quay

                        
7

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
38

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A nitro-dihydro-imidazooxazole antibiotic that inhibits mycobacterial cell wall synthesis by blocking the production of methoxy- and keto-mycolic acids, used for multidrug-resistant tuberculosis. It is reserved for TB cases where other options have been exhausted.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Delamanid is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL218650.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6480466.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.