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Dobutamine

CHEMBL926 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
301.4 g/mol
LogP
3.4
Phase
4

A synthetic catecholamine used intravenously to treat acute heart failure and cardiogenic shock by stimulating beta-1 adrenergic receptors in the heart, increasing the strength of cardiac contractions and improving cardiac output. It is also used in pharmacological cardiac stress testing (dobutamine stress echocardiography). It can cause increased heart rate and must be used with continuous cardiac monitoring.

Khối lượng phân tử

301,4000 g/mol

LogP

3,40

TPSA

72,70 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Bladder Cancer Cardiovascular Disease Non-Small Cell Lung Cancer Asthma Chronic Obstructive Pulmonary Disease Chronic Kidney Disease Hypertension Breast Cancer Heart Failure

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(CCc1ccc(O)cc1)NCCc1ccc(O)c(O)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H23NO3

                    

                    
                    

                        
HBD / HBA

                        
4 / 4

                    

                    
                    

                        
Liên kết có thể quay

                        
7

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A synthetic catecholamine used intravenously to treat acute heart failure and cardiogenic shock by stimulating beta-1 adrenergic receptors in the heart, increasing the strength of cardiac contractions and improving cardiac output. It is also used in pharmacological cardiac stress testing (dobutamine stress echocardiography). It can cause increased heart rate and must be used with continuous cardiac monitoring.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Dobutamine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL926.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 36811.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.