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Guanethidine

CHEMBL765 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
198.3 g/mol
LogP
0.5
Phase
4

An antihypertensive medication that works by preventing the release of norepinephrine from peripheral sympathetic nerves, significantly reducing blood pressure in patients with moderate to severe hypertension. It was widely used before more modern antihypertensives became available but fell out of favor due to significant orthostatic hypotension and other side effects. It still sees occasional use in specialized clinical situations such as ophthalmic drops for glaucoma.

Khối lượng phân tử

198,3100 g/mol

LogP

0,50

TPSA

67,60 Ų

Lipinski RO5

Đạt

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
N=C(N)NCCN1CCCCCCC1

                

                

                
                

                    
InChI

                    
InChI=1S/C10H22N4/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14/h1-9H2,(H4,11,12,13)

                

                

                

                    
                    

                        
Molecular Formula

                        
C10H22N4

                    

                    
                    

                        
HBD / HBA

                        
2 / 2

                    

                    
                    

                        
Liên kết có thể quay

                        
3

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
14

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
An antihypertensive medication that works by preventing the release of norepinephrine from peripheral sympathetic nerves, significantly reducing blood pressure in patients with moderate to severe hypertension. It was widely used before more modern antihypertensives became available but fell out of favor due to significant orthostatic hypotension and other side effects. It still sees occasional use in specialized clinical situations such as ophthalmic drops for glaucoma.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Guanethidine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL765.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3518.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.