Hetacillin
A penicillin-class antibiotic that is a prodrug of ampicillin, rapidly converted to ampicillin in the body after absorption to exert its antibacterial effects. It was designed to improve oral bioavailability compared to early ampicillin formulations. Its spectrum of activity and uses are equivalent to those of ampicillin.
Khối lượng phân tử
389,5000 g/mol
LogP
-0,60
TPSA
115,00 Ų
Lipinski RO5
Đạt
Cơ chế tác dụng
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
CC1(C)S[C@@H]2[C@H](N3C(=O)[C@@H](c4ccccc4)NC3(C)C)C(=O)N2[C@H]1C(=O)O
InChI
InChI=1S/C19H23N3O4S/c1-18(2)13(17(25)26)21-15(24)12(16(21)27-18)22-14(23)11(20-19(22,3)4)10-8-6-5-7-9-10/h5-9,11-13,16,20H,1-4H3,(H,25,26)/t11-,12-,13+,16-/m1/s1
Molecular Formula
C19H23N3O4S
HBD / HBA
2 / 6
Liên kết có thể quay
3
Nguyên tử nặng
27
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
A penicillin-class antibiotic that is a prodrug of ampicillin, rapidly converted to ampicillin in the body after absorption to exert its antibacterial effects. It was designed to improve oral bioavailability compared to early ampicillin formulations. Its spectrum of activity and uses are equivalent to those of ampicillin.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Hetacillin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201116. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 443387. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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