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Hydroxyurea

CHEMBL467 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
76.1 g/mol
LogP
-1.8
Phase
4

This oral chemotherapy drug works by inhibiting an enzyme called ribonucleotide reductase, slowing the growth of rapidly dividing cells. It is used to treat sickle cell disease (by increasing fetal hemoglobin), certain leukemias, and polycythemia vera. Regular blood count monitoring is essential during treatment.

Khối lượng phân tử

76,0550 g/mol

LogP

-1,80

TPSA

75,40 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Rheumatoid Arthritis Chronic Obstructive Pulmonary Disease Multiple Sclerosis Chronic Kidney Disease Stroke Lymphoma Hypertension Breast Cancer Chronic Pain Malaria HIV/AIDS Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
NC(=O)NO

                

                

                
                

                    
InChI

                    
InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)

                

                

                

                    
                    

                        
Molecular Formula

                        
CH4N2O2

                    

                    
                    

                        
HBD / HBA

                        
3 / 2

                    

                    
                    

                        
Liên kết có thể quay

                        
0

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
5

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
This oral chemotherapy drug works by inhibiting an enzyme called ribonucleotide reductase, slowing the growth of rapidly dividing cells. It is used to treat sickle cell disease (by increasing fetal hemoglobin), certain leukemias, and polycythemia vera. Regular blood count monitoring is essential during treatment.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Hydroxyurea is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL467.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 3657.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.