Iobenguane
This compound is a guanethidine analogue that, when labeled with radioactive iodine, is used for imaging or treating tumors of the adrenal medulla (pheochromocytoma) and related neuroendocrine tumors. It accumulates in these tumors due to active uptake by norepinephrine transporters. The radioactive form allows both diagnostic scanning and targeted radiation therapy.
Khối lượng phân tử
275,0900 g/mol
LogP
1,00
TPSA
64,40 Ų
Lipinski RO5
Đạt
Lĩnh vực điều trị
Cơ chế tác dụng
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Cấu trúc 2D
Cite this structure
Embed this structure
SMILES
N=C(N)NCc1cccc(I)c1
InChI
InChI=1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)
Molecular Formula
C8H10IN3
HBD / HBA
2 / 1
Liên kết có thể quay
2
Nguyên tử nặng
12
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
This compound is a guanethidine analogue that, when labeled with radioactive iodine, is used for imaging or treating tumors of the adrenal medulla (pheochromocytoma) and related neuroendocrine tumors. It accumulates in these tumors due to active uptake by norepinephrine transporters. The radioactive form allows both diagnostic scanning and targeted radiation therapy.
Functions as a diagnostic agent by providing contrast enhancement or radioactive tracer activity that enables visualization of anatomical structures or physiological processes during medical imaging.
Yes, Iobenguane is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL818. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 60860. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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