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Isosorbide Dinitrate

CHEMBL6622 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
236.1 g/mol
LogP
1.3
Phase
4

This nitrate vasodilator is used to treat and prevent angina pectoris (chest pain) and to reduce the symptoms of heart failure. It works by releasing nitric oxide, which relaxes vascular smooth muscle and widens blood vessels, reducing the workload on the heart. Tolerance can develop with continuous use, so nitrate-free intervals are recommended.

Khối lượng phân tử

236,1400 g/mol

LogP

1,30

TPSA

129,00 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Glaucoma Cardiovascular Disease Osteoporosis Stroke Obesity Type 2 Diabetes Hypertension Atopic Dermatitis Heart Failure

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
O=[N+]([O-])O[C@H]1CO[C@H]2[C@@H]1OC[C@H]2O[N+](=O)[O-]

                

                

                
                

                    
InChI

                    
InChI=1S/C6H8N2O8/c9-7(10)15-3-1-13-6-4(16-8(11)12)2-14-5(3)6/h3-6H,1-2H2/t3-,4+,5-,6-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C6H8N2O8

                    

                    
                    

                        
HBD / HBA

                        
- / 8

                    

                    
                    

                        
Liên kết có thể quay

                        
2

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
16

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
This nitrate vasodilator is used to treat and prevent angina pectoris (chest pain) and to reduce the symptoms of heart failure. It works by releasing nitric oxide, which relaxes vascular smooth muscle and widens blood vessels, reducing the workload on the heart. Tolerance can develop with continuous use, so nitrate-free intervals are recommended.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Isosorbide Dinitrate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL6622.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6883.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.