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Lumefantrine

CHEMBL38827 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
528.9 g/mol
LogP
8.7
Phase
4

This antimalarial drug is used exclusively in combination with artemether to treat uncomplicated malaria caused by Plasmodium falciparum, including strains resistant to older drugs like chloroquine. It works by accumulating in infected red blood cells and interfering with the parasite's ability to detoxify heme, a byproduct of its digestion of hemoglobin.

Khối lượng phân tử

528,9000 g/mol

LogP

8,70

TPSA

23,50 Ų

Lipinski RO5

Không đạt

Lĩnh vực điều trị

Malaria HIV/AIDS Tuberculosis

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCCCN(CCCC)CC(O)c1cc(Cl)cc2c1-c1ccc(Cl)cc1/C2=C/c1ccc(Cl)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-

                

                

                

                    
                    

                        
Molecular Formula

                        
C30H32Cl3NO

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
Liên kết có thể quay

                        
10

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
35

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
This antimalarial drug is used exclusively in combination with artemether to treat uncomplicated malaria caused by Plasmodium falciparum, including strains resistant to older drugs like chloroquine. It works by accumulating in infected red blood cells and interfering with the parasite's ability to detoxify heme, a byproduct of its digestion of hemoglobin.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Lumefantrine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL38827.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6437380.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.