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Methylprednisolone

CHEMBL650 Phase 4 Đã phê duyệt Small molecule
Half-Life
18-36 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
374.5 g/mol
LogP
1.9
Phase
4

An intermediate-acting synthetic glucocorticoid, methylprednisolone suppresses inflammation and immune activity across a wide range of conditions, including severe allergic reactions, asthma flares, rheumatoid arthritis, and multiple sclerosis relapses. Available in oral, injectable, and topical forms and marketed as Medrol and Depo-Medrol, it has the formula C22H30O5. Its potency relative to older steroids allows effective control of acute inflammatory episodes.

A corticosteroid used to treat a wide range of inflammatory and autoimmune conditions, including allergic reactions, asthma flares, rheumatoid arthritis, and multiple sclerosis relapses. It is available in oral, injectable, and topical forms.

Khối lượng phân tử

374,4710 g/mol

LogP

1,90

TPSA

94,80 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Neurology Immunology Asthma Rheumatoid Arthritis Multiple Sclerosis Rheumatology

Phân loại thuốc

H — H - Systemic Hormonal Preparations, Excluding Sex Hormones and Insulins

Cơ chế tác dụng

Intermediate-acting synthetic glucocorticoid.

Pharmacokinetics (PK)

Half-Life 18-36 hours

Pharmacodynamics (PD)

Cơ chế

Intermediate-acting synthetic glucocorticoid.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
C[C@H]1C[C@@H]2[C@H]([C@@H](O)C[C@@]3(C)[C@H]2CC[C@]3(O)C(=O)CO)[C@@]2(C)C=CC(=O)C=C12

                

                

                
                

                    
InChI

                    
InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H30O5

                    

                    
                    

                        
HBD / HBA

                        
3 / 5

                    

                    
                    

                        
Liên kết có thể quay

                        
2

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
27

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                

                    
                    
                        

                            

  
  Moderate


                            
                                Methylprednisolone + Diltiazem
                            
                        

                        
                        
Diltiazem inhibits CYP3A4-mediated methylprednisolone metabolism, increasing methylprednisolone exposure and the risk of steroid side effects including immunosuppression, hyperglycaemia, and hypertension.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Methylprednisolone + Fluconazole
                            
                        

                        
                        
Fluconazole inhibits CYP3A4-mediated metabolism of methylprednisolone, increasing its plasma levels and prolonging corticosteroid effects, raising the risk of Cushingoid features.

                        
                    
                    
                    
                        

                            

  
  Moderate


                            
                                Methylprednisolone + Cyclosporine
                            
                        

                        
                        
Methylprednisolone inhibits CYP3A4-mediated cyclosporine metabolism, raising cyclosporine levels; conversely, cyclosporine may increase methylprednisolone exposure — a bidirectional pharmacokinetic interaction.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A corticosteroid used to treat a wide range of inflammatory and autoimmune conditions, including allergic reactions, asthma flares, rheumatoid arthritis, and multiple sclerosis relapses. It is available in oral, injectable, and topical forms.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Intermediate-acting synthetic glucocorticoid.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Methylprednisolone: Half-life: 18-36 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Methylprednisolone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Levothyroxine
                            Small molecule
                        
                        
                        
                            Prednisone
                            Small molecule
                        
                        
                        
                            Dexamethasone
                            Small molecule
                        
                        
                    

                

                

                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL650.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6741.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.