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Pipecuronium

CHEMBL1201206 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
602.9 g/mol
LogP
4.5
Phase
4

Pipecuronium is a long-acting non-depolarizing neuromuscular blocking agent of the aminosteroid class that competitively antagonizes acetylcholine at nicotinic receptors at the neuromuscular junction, producing skeletal muscle relaxation. It is used as an adjunct to general anesthesia during surgical procedures requiring prolonged muscle relaxation, particularly in patients with cardiovascular disease due to its minimal cardiovascular effects.

Khối lượng phân tử

602,9000 g/mol

LogP

4,50

TPSA

59,10 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Cardiovascular Disease Atrial Fibrillation

Cơ chế tác dụng

Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@H](CC[C@@]4(C)[C@H]3C[C@H](N3CC[N+](C)(C)CC3)[C@@H]4OC(C)=O)[C@@]2(C)C[C@@H]1N1CC[N+](C)(C)CC1

                

                

                
                

                    
InChI

                    
InChI=1S/C35H62N4O4/c1-24(40)42-32-21-26-9-10-27-28(35(26,4)23-31(32)37-15-19-39(7,8)20-16-37)11-12-34(3)29(27)22-30(33(34)43-25(2)41)36-13-17-38(5,6)18-14-36/h26-33H,9-23H2,1-8H3/q+2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C35H62N4O4+2

                    

                    
                    

                        
HBD / HBA

                        
- / 6

                    

                    
                    

                        
Liên kết có thể quay

                        
6

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
43

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Pipecuronium is a long-acting non-depolarizing neuromuscular blocking agent of the aminosteroid class that competitively antagonizes acetylcholine at nicotinic receptors at the neuromuscular junction, producing skeletal muscle relaxation. It is used as an adjunct to general anesthesia during surgical procedures requiring prolonged muscle relaxation, particularly in patients with cardiovascular disease due to its minimal cardiovascular effects.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Pipecuronium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201206.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 50192.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.