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Plicamycin

CHEMBL1237054 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
1085.1 g/mol
LogP
0.6
Phase
4

Plicamycin (mithramycin) is an antineoplastic antibiotic produced by Streptomyces plicatus that intercalates into DNA and inhibits RNA synthesis by binding to the DNA double helix in a GC-rich region, blocking the action of RNA polymerase. It was used in the treatment of testicular cancer and hypercalcemia of malignancy, and has shown activity in breast cancer and lung cancer, though its use is limited by significant toxicity.

Khối lượng phân tử

1085,1000 g/mol

LogP

0,60

TPSA

358,00 Ų

Lipinski RO5

Không đạt

Lĩnh vực điều trị

Non-Small Cell Lung Cancer Breast Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CO[C@H](C(=O)[C@@H](O)[C@@H](C)O)[C@@H]1Cc2cc3cc(O[C@H]4C[C@@H](O[C@@H]5C[C@@H](O)[C@H](O)[C@@H](C)O5)[C@H](O)[C@@H](C)O4)c(C)c(O)c3c(O)c2C(=O)[C@H]1O[C@H]1C[C@@H](O[C@@H]2C[C@@H](O)[C@@H](O[C@@H]3C[C@](C)(O)[C@H](O)[C@@H](C)O3)[C@@H](C)O2)[C@H](O)[C@@H](C)O1

                

                

                
                

                    
InChI

                    
InChI=1S/C52H76O24/c1-18-30(72-35-15-31(43(59)21(4)68-35)73-33-13-28(54)42(58)20(3)67-33)12-26-10-25-11-27(49(66-9)47(63)41(57)19(2)53)50(46(62)39(25)45(61)38(26)40(18)56)75-36-16-32(44(60)22(5)69-36)74-34-14-29(55)48(23(6)70-34)76-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-29,31-37,41-44,48-51,53-61,64-65H,11,13-17H2,1-9H3/t19-,20-,21-,22-,23-,24-,27+,28-,29-,31-,32-,33-,34-,35+,36+,37-,41+,42-,43-,44-,48+,49+,50+,51-,52+/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C52H76O24

                    

                    
                    

                        
HBD / HBA

                        
11 / 24

                    

                    
                    

                        
Liên kết có thể quay

                        
15

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
76

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Plicamycin (mithramycin) is an antineoplastic antibiotic produced by Streptomyces plicatus that intercalates into DNA and inhibits RNA synthesis by binding to the DNA double helix in a GC-rich region, blocking the action of RNA polymerase. It was used in the treatment of testicular cancer and hypercalcemia of malignancy, and has shown activity in breast cancer and lung cancer, though its use is limited by significant toxicity.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Plicamycin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1237054.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 163659.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.