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Pronetalol

CHEMBL16476 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
229.3 g/mol
LogP
3.0
Phase
4

Pronetalol was the first clinically used beta-adrenergic receptor blocker, blocking both beta-1 and beta-2 adrenergic receptors to reduce heart rate, myocardial contractility, and the chronotropic response to catecholamines. It was withdrawn shortly after introduction due to thymic tumors in animal studies, but its discovery by James Black led to the development of propranolol and the broader class of beta-blockers.

Khối lượng phân tử

229,3200 g/mol

LogP

3,00

TPSA

32,30 Ų

Lipinski RO5

Đạt

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC(C)NCC(O)c1ccc2ccccc2c1

                

                

                
                

                    
InChI

                    
InChI=1S/C15H19NO/c1-11(2)16-10-15(17)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11,15-17H,10H2,1-2H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C15H19NO

                    

                    
                    

                        
HBD / HBA

                        
2 / 2

                    

                    
                    

                        
Liên kết có thể quay

                        
4

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
17

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Pronetalol was the first clinically used beta-adrenergic receptor blocker, blocking both beta-1 and beta-2 adrenergic receptors to reduce heart rate, myocardial contractility, and the chronotropic response to catecholamines. It was withdrawn shortly after introduction due to thymic tumors in animal studies, but its discovery by James Black led to the development of propranolol and the broader class of beta-blockers.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Pronetalol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL16476.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4930.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.