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Propranolol

CHEMBL27 Phase 4 Đã phê duyệt Small molecule
Half-Life
3-6 hours
Bioavailability
—
Protein Binding
—
Molecular Weight
259.3 g/mol
LogP
3.0
Phase
4

A beta-blocker used to treat a wide variety of conditions including high blood pressure, angina, irregular heart rhythms, tremors, anxiety, and prevention of migraines and heart attacks. It works by blocking the effects of adrenaline on the heart and blood vessels, slowing the heart rate and reducing blood pressure.

Khối lượng phân tử

259,3440 g/mol

LogP

3,00

TPSA

41,50 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Cardiovascular Disease Age-Related Macular Degeneration Pain Management Non-Small Cell Lung Cancer Osteoporosis Asthma Chronic Obstructive Pulmonary Disease Parkinson's Disease Epilepsy Migraine Schizophrenia Generalized Anxiety Disorder Melanoma Multiple Sclerosis Chronic Kidney Disease Non-Alcoholic Fatty Liver Disease Stroke Obesity Type 2 Diabetes Hypertension Major Depressive Disorder Breast Cancer Chronic Pain Hepatitis C Heart Failure Atrial Fibrillation Prostate Cancer Colorectal Cancer

Phân loại thuốc

C — C - Cardiovascular System

Cơ chế tác dụng

Non-selective beta-adrenergic receptor blocker.

Pharmacokinetics (PK)

Half-Life 3-6 hours

Pharmacodynamics (PD)

Cơ chế

Non-selective beta-adrenergic receptor blocker.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC(C)NCC(O)COc1cccc2ccccc12

                

                

                
                

                    
InChI

                    
InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H21NO2

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
Liên kết có thể quay

                        
6

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
19

                    

                    
                

            


            
            

                
                

                    
                    

                        

                            ADRB1 (Beta-1 Adrenergic Receptor)
                            Antagonist
                        

                        
                        Primary Target
                        
                    

                    
                    

                        

                            ADRB2 (Beta-2 Adrenergic Receptor)
                            Antagonist
                        

                        
                    

                    
                

                
            


            
            

                
                

                    
                    
                        

                            

  
  Major


                            
                                Propranolol + Albuterol
                            
                        

                        
                        
Propranolol, a non-selective beta-blocker, directly antagonises the bronchodilatory and cardiovascular effects of albuterol, potentially causing severe bronchospasm in patients with asthma or COPD.

                        
                    
                    
                

                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
A beta-blocker used to treat a wide variety of conditions including high blood pressure, angina, irregular heart rhythms, tremors, anxiety, and prevention of migraines and heart attacks. It works by blocking the effects of adrenaline on the heart and blood vessels, slowing the heart rate and reducing blood pressure.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Non-selective beta-adrenergic receptor blocker.

                        

                    

                    

                    
                    

                        
                        

                            
Key pharmacokinetic parameters for Propranolol: Half-life: 3-6 hours.

                        

                    

                    

                    

                        
                        

                            
Yes, Propranolol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            
            

                
Related Drugs


                
                

                    
Same Drug Class

                    

                        
                        
                            Atorvastatin
                            Small molecule
                        
                        
                        
                            Amlodipine
                            Small molecule
                        
                        
                        
                            Lisinopril
                            Small molecule
                        
                        
                        
                            Metoprolol
                            Small molecule
                        
                        
                    

                

                

                
                
                
            

            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL27.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4946.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.