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Sulfanilamide

CHEMBL21 Phase 4 Đã phê duyệt Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
172.2 g/mol
LogP
-0.6
Phase
4

Sulfanilamide is the prototype sulfonamide antibiotic and the parent compound from which all sulfonamide drugs are derived, used topically for vaginal candidiasis and bacterial vaginitis and historically as a systemic antibacterial before more effective agents were available. It acts as a structural analog of para-aminobenzoic acid (PABA), competitively inhibiting dihydropteroate synthase and blocking bacterial folic acid biosynthesis. It is also the precursor of carbonic anhydrase inhibitors and thiazide diuretics through chemical modification.

Khối lượng phân tử

172,2100 g/mol

LogP

-0,60

TPSA

94,60 Ų

Lipinski RO5

Đạt

Lĩnh vực điều trị

Non-Small Cell Lung Cancer Colorectal Cancer

Cơ chế tác dụng

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Cơ chế

Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

Cấu trúc 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Nc1ccc(S(N)(=O)=O)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)

                

                

                

                    
                    

                        
Molecular Formula

                        
C6H8N2O2S

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
Liên kết có thể quay

                        
1

                    

                    
                    
                    

                        
Nguyên tử nặng

                        
11

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Câu hỏi thường gặp

                

                    
                    

                        
                        

                            
Sulfanilamide is the prototype sulfonamide antibiotic and the parent compound from which all sulfonamide drugs are derived, used topically for vaginal candidiasis and bacterial vaginitis and historically as a systemic antibacterial before more effective agents were available. It acts as a structural analog of para-aminobenzoic acid (PABA), competitively inhibiting dihydropteroate synthase and blocking bacterial folic acid biosynthesis. It is also the precursor of carbonic anhydrase inhibitors and thiazide diuretics through chemical modification.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Sulfanilamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL21.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5333.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
Tuyên bố miễn trách y tế

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.