Tocofersolan
Tocofersolan (TPGS, d-alpha-tocopheryl polyethylene glycol 1000 succinate) is a water-soluble form of vitamin E (alpha-tocopherol) conjugated to polyethylene glycol via a succinate ester, used to treat vitamin E deficiency in children with congenital chronic cholestasis or hereditary chronic cholestasis where fat-soluble vitamin absorption is severely impaired. Its water-soluble nature allows intestinal absorption independent of bile acids, which are deficient in cholestatic liver disease. It is also used as a pharmaceutical solubilizer and bioavailability enhancer for poorly water-soluble drugs.
Lĩnh vực điều trị
Cơ chế tác dụng
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.
HBD / HBA
- / -
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Câu hỏi thường gặp
Tocofersolan (TPGS, d-alpha-tocopheryl polyethylene glycol 1000 succinate) is a water-soluble form of vitamin E (alpha-tocopherol) conjugated to polyethylene glycol via a succinate ester, used to treat vitamin E deficiency in children with congenital chronic cholestasis or hereditary chronic cholestasis where fat-soluble vitamin absorption is severely impaired. Its water-soluble nature allows intestinal absorption independent of bile acids, which are deficient in cholestatic liver disease. It is also used as a pharmaceutical solubilizer and bioavailability enhancer for poorly water-soluble drugs.
Serves as an essential micronutrient cofactor in various enzymatic reactions and metabolic processes. Supplementation corrects deficiency states and supports normal physiological function.
Yes, Tocofersolan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2108106. Open-access bioactivity database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.
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